Musculoskeletal, Metabolic, Or Multisystem
Abnormal Findings and Pathophysiological Changes
Musculoskeletal dysfunction results from a misalignment between the external load and the human body’s ability to withstand the physiological and biomechanical strain. Excessive forces cause a variety of pathophysiological processes depending on the affected tissues. As a result, sensory innervation of joints, bones, and muscles differs. It also has an impact on the peripheral and central nervous systems. The interaction between neurons and non-neural cells sensitizes and amplifies pain signals, resulting in cortical remodeling. It can also cause inflammatory diseases like vasculitis and connective tissue disease. Aching and stiffness, muscle cramps, pain when moving, fatigue, a burning sensation in the muscles, and sleep disturbances are common symptoms of musculoskeletal dysfunction. These symptoms significantly impact the patient’s ability to move by increasing joint pain. The patient suffers from severe muscle pain, which reduces their quality of life.
Different pathophysiological changes and abnormal findings indicate metabolic health dysfunction. It causes insulin resistance, chronic inflammation, and neurohormonal activation, which results in high blood sugar, high blood pressure, obesity, and an impressive triglyceride range (Rochlani et al., 2017). Depending on the type of disorder, the symptoms of metabolic dysfunction differ. Some symptoms are mild and can be managed with medication and lifestyle changes, while others cause severe symptoms such as seizures, breathing difficulties, and organ failure. Muscle cramping, fatigue, chronic or persistent diarrhea, and nausea are some of the other symptoms. The patient’s functioning is impacted in a variety of ways. The patient complains of shortness of breath, wheezing, mood swings, and confusion.
Immune dysregulation, macrophage dysfunction, altered coagulation with bleeding and thrombosis, malignant intravascular inflammation, circulatory derangements, pulmonary dysfunction, and loss of microvascular homeostasis are all symptoms of multisystem health dysfunction. It is linked to sepsis, a clinical syndrome characterized by widespread tissue injury and systematic inflammation caused by a severe infection (Carcillo et al., 2017). Low-grade fever, anxiety, and malaise are common symptoms. These symptoms make it difficult for the patient to live an everyday life, and they may suffer from frequent shock, organ failure, and low blood PH.